Yes, it does differ throughout the state…It’s common in the more rural parts of Missouri for people to pronounce it Missoura and in the more urban areas it’s pronounced Missouri. Another interesting thing: my grandma’s name is Naomi, and, I believe, most people pronounce it Naomee, but, to show how the pronunciations differ throughout the state, my great grandma (my grandma’s mom) always pronounced it Naoma.