Red Heart is a #4 worsted weight. Woolese chunky is a #5 bulky. They also have Woolese Thick and Quick which is a #6 superbulky. Assuming you have the chunky, you would have a #4 and a #5. So I would say, no you can’t use them together. The gauge on the two would differ. As far as type, the acrylic and wool blend should be okay. From the posts I’m reading, the wool blends don’t shrink. It’s your project and you can do it any old way you want to. The only ones I wouldn’t put together would be an acrylic and 100% wool. The wool parts would shrink in the washer.