I have only worked with 100% wool twice. The first time, I used tapestry wool skeins I picked up at Salvation Army (made coasters to felt). Now, I'm knitting a Kitty Pi bed to felt.
I am having quite an allergic reaction to this yarn! My face has been itchy (no breaking out, though), and my eyes have alternately burned and itched, and I've been sneezing alot. It's not so bad that I'm miserable and cannot stand to finish, but I am definitely allergic. I'm using Lambs Pride Bulky yarn. I didn't have this reaction with the small skeins of tapestry wool that I used for the coasters.
I am planning on making my some scarves and gloves and mittens out of soft wool yarns, for my daughter for Christmas. She lives in Germany, in a very cold winter climate. When home, her allergies to various things were far worse than mine, so now I'm concerned about using wool for her garments, for fear of her having an allergic reaction. Are some wools more bothersome to you who suffer than others?