I can't knit with acrylic for too long or it makes my hands hot and itchy. But....I don't have much of a choice. I just don't have the money to be buying anything else, either online or in a store. I've found that no matter what, there's always going to be two very definite sides to this battle.
While I like wool, and I can spend hours in a yarn shop petting balls and hanks and skeins, I normally walk out with nothing. There are so many different types of fibers out there...natural, synthetic, blends, etc, that there will always be something for everyone.
On a side note...I absolutely HATE the way Noro feels. It seems there's been such a fuss over how lovely this yarn is, but I refuse to buy it. It feels icky (to me anyways).