Yes, quite a bit...although I don't have a preference for Magic Loop over DPNs or vice versa. I'll use whatever works. I find each as fiddly as the other, or perhaps that should be "just as non-fiddly as the other".
There are times when certain tasks are easier without the loops in the way, and other times when too many sticks in the mix are unwieldy. So I just switch if necessary.