I'm making a "manly" scarf with the following pattern:
worsted weight yarn (350 yards)
size 11 needles
CO 21 stitches
Row 1: K1 P1, repeat to last stitch, k last stitch.
Row 2: K all stitches.
gauge: 4"=15-1/2 stiches/16 rows
finished size 7 x 50 (or thereabouts)
This is going really fast, is a nice non-gender pattern.
I think you could use different weights of yarn and size needles as long as it was done on an uneven number of stitches.